MACSima is a revolutionary 3D imaging platform developed by Miltenyi Biotec, combining hyperplex staining with an automated image acquisition and analysis system.
It is designed for highly multiplexed microscopy, enabling in-depth and detailed analysis of the expression of over 150 proteins on a single tissue section or cell sample. This system is based on the patented MACSima Imaging Cyclic Staining (MICS) technology, offering unprecedented capacity to simultaneously examine hundreds of markers on a single sample.
The system is based on the REAfinity technology, which employs standardized recombinant antibodies to ensure high specificity and reproducibility of results, while reducing background noise thanks to the absence of secondary antibodies. A catalog of over 600 biomarkers is available, along with the option to design custom panels.
MACSima combines advanced fluorescence microscopy capable of detecting signals at the subcellular level, with spatial and functional analysis enabled by repeated imaging on a single sample. The platform is fully automated for staining, image acquisition, and data processing. It is compatible with all types of fixed samples, including paraffin-embedded tissues (FFPE), fresh or frozen sections, cells in suspension, and organoids.
Data analysis is automated through the MACS iQ View software, which allows for quantitative fluorescence analysis, spatial mapping of proteins and RNA in complex structures, as well as precise identification of cell types and their interactions, enabling rapid generation of publication-ready results.
By combining automation, precision, and multiplexing, the MACSima platform provides an integrated and comprehensive view of biological processes at the molecular level. This makes it an essential tool for exploring the complexity of tissues and cells in various research contexts.
For more information, you can visit Miltenyi Biotec website.
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